Anti-KIN抗体[2490D1a] (ab67100)

概述

  • 产品名称Anti-KIN抗体[2490D1a]
    参阅全部 KIN 一抗
  • 描述
    小鼠单克隆抗体[2490D1a] to KIN
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment (Human) from an internal sequence of KIN.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum and was filtered through a 0.22µm membrane.
  • 克隆单克隆
  • 克隆编号2490D1a
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab67100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
Dot blot
  • 应用说明Dot: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Detects a band of approximately 32 kDa (predicted molecular weight of full length protein: 45 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.
    • 组织特异性Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level).
    • 序列相似性Belongs to the KIN17 family.
      Contains 1 C2H2-type zinc finger.
    • 结构域The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding.
    • 细胞定位Nucleus. Cytoplasm. During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids.
    • Information by UniProt
    • 数据库链接
    • 别名
      • antigenic determinant of recA protein homolog antibody
      • Binding to curved DNA antibody
      • BTCD antibody
      • DNA/RNA-binding protein KIN17 antibody
      • HsKin17 protein antibody
      • KIN antibody
      • KIN antigenic determinant of recA protein homolog mouse antibody
      • Kin17 protein antibody
      • KIN17_HUMAN antibody
      see all

    Anti-KIN antibody [2490D1a] 图像

    Anti-KIN antibody [2490D1a] (ab67100)参考文献

    ab67100 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab67100.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"