概述

  • 产品名称Anti-Kidins220 (phospho S919)抗体
    参阅全部 Kidins220 一抗
  • 描述
    兔多克隆抗体to Kidins220 (phospho S919)
  • 特异性This antibody recognizes a phosphoserine at position 919.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Pufferfish (Fugu), Non Human Primates, Zebrafish
  • 免疫原

    Synthetic peptide: RQMQRTITRQMpSFDLTK, corresponding to amino acids 907-923 of Human Kidins220

性能

应用

Our Abpromise guarantee covers the use of ab34792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 220 kDa.

靶标

  • 功能Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • 组织特异性Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • 序列相似性Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • 结构域The transmembrane domain mediates interaction with NTRK1.
  • 翻译后修饰Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all

Anti-Kidins220 (phospho S919) antibody (ab34792)参考文献

This product has been referenced in:
  • Li J  et al. PKD1, PKD2, and Their Substrate Kidins220 Regulate Neurotensin Secretion in the BON Human Endocrine Cell Line. J Biol Chem 283:2614-21 (2008). WB ; Human . Read more (PubMed: 18048355) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab34792.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"