概述

  • 产品名称Anti-Kidins220抗体
    参阅全部 Kidins220 一抗
  • 描述
    兔多克隆抗体to Kidins220
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 1517-1547 of Human Kidins220 (Accessions: Q9ULH0, NP_065789.1)

  • 阳性对照
    • K562 cell line lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab124194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 197 kDa.

靶标

  • 功能Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • 组织特异性Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • 序列相似性Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • 结构域The transmembrane domain mediates interaction with NTRK1.
  • 翻译后修饰Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all

Anti-Kidins220 antibody 图像

  • Anti-Kidins220 antibody (ab124194) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 197 kDa

Anti-Kidins220 antibody (ab124194)参考文献

ab124194 has not yet been referenced specifically in any publications.

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