概述

  • 产品名称Anti-KIAA1967抗体
    参阅全部 KIAA1967 一抗
  • 描述
    兔多克隆抗体to KIAA1967
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1 and 50 of Human KIAA1967 (UniProt: Q8N163).

  • 阳性对照
    • Human: breast carcinoma, colon carcinoma, metastatic lymph node, ovarian carcinoma, pancreatic islet cell tumor, skin basal cell carcinoma, stomach adenocarcinoma, testicular seminoma. Mouse: squamous cell carcinoma.
  • 常规说明

    Concentration is optimized for IHC and not determined

性能

应用

Our Abpromise guarantee covers the use of ab84384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.
    • 组织特异性Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CCAR2 antibody
      • Cell cycle and apoptosis regulator 2 antibody
      • Cell division cycle and apoptosis regulator protein 2 antibody
      • DBC-1 antibody
      • DBC.1 antibody
      • DBC1 antibody
      • DBIRD complex subunit KIAA1967 antibody
      • Deleted in breast cancer 1 antibody
      • Deleted in breast cancer gene 1 protein antibody
      • K1967_HUMAN antibody
      • KIAA1967 antibody
      • NET35 antibody
      • p30 DBC antibody
      • p30 DBC protein antibody
      • p30DBC antibody
      see all

    Anti-KIAA1967 antibody 图像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast tumor tissue using 1/250 ab84384, followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma tissue using 1/250 ab84384, followed by DAB staining.

    Anti-KIAA1967 antibody (ab84384)参考文献

    This product has been referenced in:
    • Cha EJ  et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 15:4453-9 (2009). Read more (PubMed: 19509139) »

    See 1 Publication for this product

    Product Wall

    Vielen Dank für Ihre Anfrage.
    Leider gibt der Hersteller dieses Antikörpers keine genauen Konzentrationsangaben weiter.
    Ich möchte Sie deshalb bitten eine Konzentration von ca. 1mg/ml anzunehmen, falls Sie eine Isotypen-Kontrolle verwenden. <...

    Read More

    Vielen Dank für Ihre Anfrage. Ich kann Ihnen nun bestätigen, dass ab84384 (Anti-DBC1 antibody) eine Konzentration von ca. 1mg/ml hat. Außerdem kann ich Ihnen bestätigen, dass das Lot, das im Moment von ab114033 (Anti-CD26 antibody [11D7]) vorrätig i...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"