概述

  • 产品名称Anti-KIAA1967抗体
    参阅全部 KIAA1967 一抗
  • 描述
    兔多克隆抗体to KIAA1967
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 650 and 700 of Human KIAA1967 (UniProt: Q8N163)

  • 阳性对照
    • Nuclear extract from HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab70240 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 120 kDa (predicted molecular weight: 103 kDa).
IP Use at 1-10 µg/mg of lysate.

靶标

  • 功能Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.
  • 组织特异性Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CCAR2 antibody
    • Cell cycle and apoptosis regulator 2 antibody
    • Cell division cycle and apoptosis regulator protein 2 antibody
    • DBC-1 antibody
    • DBC.1 antibody
    • DBC1 antibody
    • DBIRD complex subunit KIAA1967 antibody
    • Deleted in breast cancer 1 antibody
    • Deleted in breast cancer gene 1 protein antibody
    • K1967_HUMAN antibody
    • KIAA1967 antibody
    • NET35 antibody
    • p30 DBC antibody
    • p30 DBC protein antibody
    • p30DBC antibody
    see all

Anti-KIAA1967 antibody 图像

  • Lanes 1 - 2 : Anti-KIAA1967 antibody (ab70240) at 1/1000 dilution
    Lanes 3 - 4 : Anti-KIAA1967 antibody (ab70240) at 1/10000 dilution

    Lane 1 : Nuclear extract from HeLa cells at 15 µg
    Lane 2 : Nuclear extract from HeLa cells at 45 µg
    Lane 3 : Nuclear extract from HeLa cells at 15 µg
    Lane 4 : Nuclear extract from HeLa cells at 45 µg

    Developed using the ECL technique

    Predicted band size : 103 kDa


    Exposure time : 5 seconds

Anti-KIAA1967 antibody (ab70240)参考文献

ab70240 has not yet been referenced specifically in any publications.

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