概述

  • 产品名称
    Anti-KIAA0319抗体
    参阅全部 KIAA0319 一抗
  • 描述
    山羊多克隆抗体to KIAA0319
  • 特异性
    This antibody is expected to cross-react with mouse KIAA0319 isoform 1 (NP_001074520.1), isoform 2 (XP_994023.1) and isoform 4 (XP_913491.1).
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat
  • 免疫原

    Synthetic peptide:

    C-QGKIKQENKPTLH

    , corresponding to internal sequence amino acids 391-403 of Mouse KIAA0319 (NP_001074520.1).

  • 阳性对照
    • Mouse Brain lysate
  • 常规说明


    The variants XP_341528.2 and XP_001070349.1 represent identical protein.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab82212 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Primary antibody说明
    The variants XP_341528.2 and XP_001070349.1 represent identical protein.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab82212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 118 kDa.

靶标

  • 功能
    Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.
  • 组织特异性
    Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.
  • 疾病相关
    Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. Note=A lower expression is associated with the risk haplotype.
  • 序列相似性
    Contains 1 MANSC domain.
    Contains 5 PKD domains.
  • 发展阶段
    Expressed in the developing cerebral neocortex and glanglionic eminence in 57 days post-fertilization fetal brain.
  • 翻译后修饰
    N-glycosylated.
    O-glycosylated.
    Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus.
  • 细胞定位
    Cell membrane. Early endosome membrane. Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DLX 2 antibody
    • DLX2 antibody
    • DYLX 2 antibody
    • DYLX2 antibody
    • Dyslexia susceptibility 2 antibody
    • Dyslexia-associated protein KIAA0319 antibody
    • DYX 2 antibody
    • DYX2 antibody
    • K0319_HUMAN antibody
    • Kiaa0319 antibody
    • MGC176717 antibody
    see all

Anti-KIAA0319 antibody 图像

  • Anti-KIAA0319 antibody (ab82212) at 0.5 µg/ml + Mouse Brain lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 118 kDa
    Observed band size : 150 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 25 kDa. We are unsure as to the identity of these extra bands.

实验方案

Anti-KIAA0319 antibody (ab82212)参考文献

ab82212 has not yet been referenced specifically in any publications.

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