Anti-KIAA0319抗体(ab118923)

概述

  • 产品名称Anti-KIAA0319抗体
    参阅全部 KIAA0319 一抗
  • 描述
    兔多克隆抗体to KIAA0319
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Cow, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 151-200 (EEMSEYSDDY RELEKDLLQP SGKQEPRGSA EYTDWGLLPG SEGAFNSSVG) of Human KIAA0319 (EAW55455).

  • 阳性对照
    • HepG2 cell lysate; Human kidney tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab118923 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1.25 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.

靶标

  • 功能Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.
  • 组织特异性Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.
  • 疾病相关Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. Note=A lower expression is associated with the risk haplotype.
  • 序列相似性Contains 1 MANSC domain.
    Contains 5 PKD domains.
  • 发展阶段Expressed in the developing cerebral neocortex and glanglionic eminence in 57 days post-fertilization fetal brain.
  • 翻译后修饰N-glycosylated.
    O-glycosylated.
    Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus.
  • 细胞定位Cell membrane. Early endosome membrane. Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DLX 2 antibody
    • DLX2 antibody
    • DYLX 2 antibody
    • DYLX2 antibody
    • Dyslexia susceptibility 2 antibody
    • Dyslexia-associated protein KIAA0319 antibody
    • DYX 2 antibody
    • DYX2 antibody
    • K0319_HUMAN antibody
    • Kiaa0319 antibody
    • MGC176717 antibody
    see all

Anti-KIAA0319 antibody 图像

  • Anti-KIAA0319 antibody (ab118923) at 1.25 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 56 kDa
  • ab118923, at 8 µg/ml, staining KIAA0319 in paraffin embedded Human kidney tissue by Immunohistochemistry.
    Cells with positive label are epithelial cells of renal tubules (indicated by arrows).

Anti-KIAA0319 antibody (ab118923)参考文献

ab118923 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Human Cell lysate - whole cell (HEK293)
Gel Running Conditions Reduced Denaturing (4-10 % gradient gel)
Loading amount 100 µg
Specification HEK293
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 20°C
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提交于 Jul 21 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"