概述
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产品名称Anti-KIAA0319抗体
参阅全部 KIAA0319 一抗 -
描述兔多克隆抗体to KIAA0319
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经测试应用适用于: WB, IHC-Pmore details
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种属反应性与反应: Human
预测可用于: Horse, Cow, Pig
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免疫原
Synthetic peptide corresponding to a region within N terminal amino acids 151-200 (EEMSEYSDDY RELEKDLLQP SGKQEPRGSA EYTDWGLLPG SEGAFNSSVG) of Human KIAA0319 (EAW55455).
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阳性对照
- HepG2 cell lysate; Human kidney tissue
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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存储溶液Constituents: 97% PBS, 2% Sucrose
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Concentration information loading... -
纯度Protein A purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab118923 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 1.25 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T. | |
| IHC-P | Use a concentration of 4 - 8 µg/ml. |
靶标
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功能Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.
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组织特异性Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.
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疾病相关Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. Note=A lower expression is associated with the risk haplotype.
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序列相似性Contains 1 MANSC domain.
Contains 5 PKD domains. -
发展阶段Expressed in the developing cerebral neocortex and glanglionic eminence in 57 days post-fertilization fetal brain.
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翻译后修饰N-glycosylated.
O-glycosylated.
Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus. -
细胞定位Cell membrane. Early endosome membrane. Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.
- Information by UniProt
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数据库链接
- Entrez Gene: 520603 Cow
- Entrez Gene: 9856 Human
- Omim: 609269 Human
- SwissProt: Q5VV43 Human
- Unigene: 26441 Human
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别名
- DLX 2 antibody
- DLX2 antibody
- DYLX 2 antibody
see all
Anti-KIAA0319 antibody 图像
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Western blot - Anti-KIAA0319 antibody (ab118923)Anti-KIAA0319 antibody (ab118923) at 1.25 µg/ml + HepG2 cell lysate at 10 µg
Predicted band size : 56 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KIAA0319 antibody (ab118923)ab118923, at 8 µg/ml, staining KIAA0319 in paraffin embedded Human kidney tissue by Immunohistochemistry.
Cells with positive label are epithelial cells of renal tubules (indicated by arrows).
Anti-KIAA0319 antibody (ab118923)参考文献
ab118923 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"