Anti-Keratocan抗体(ab113115)

概述

  • 产品名称Anti-Keratocan抗体
    参阅全部 Keratocan 一抗
  • 描述
    兔多克隆抗体to Keratocan
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 227-257 of Human Keratocan (NP_008966.1).

  • 阳性对照
    • MDA-MB435 cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab113115 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.

靶标

  • 功能May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
  • 组织特异性Cornea. Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen.
  • 疾病相关Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2) [MIM:217300]. In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.
  • 序列相似性Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
    Contains 10 LRR (leucine-rich) repeats.
    Contains 1 LRRNT domain.
  • 翻译后修饰Binds keratan sulfate chains.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CNA2 antibody
    • KERA antibody
    • KERA_HUMAN antibody
    • Keratan sulfate proteoglycan keratocan antibody
    • Keratocan antibody
    • KTN antibody
    • SLRR2B antibody
    see all

Anti-Keratocan antibody 图像

  • Anti-Keratocan antibody (ab113115) at 1/100 dilution + MDA-MB435 cell line lysate at 35 µg

    Predicted band size : 41 kDa

Anti-Keratocan antibody (ab113115)参考文献

ab113115 has not yet been referenced specifically in any publications.

Product Wall

Application Flow Cytometry
Sample Human Cell (Cornea MSC)
Permeabilization Yes - Perm2 buffer
Specification Cornea MSC
Fixation Fix buffer
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提交于 Apr 04 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"