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RabMAb

Anti-Keratin 12抗体[EPR1609(2)] (ab124975)

概述

  • 产品名称
    Anti-Keratin 12抗体[EPR1609(2)]
    参阅全部 Keratin 12 一抗
  • 描述
    兔单克隆抗体[EPR1609(2)] to Keratin 12
  • 经测试应用
    适用于: WBmore details
    不适用于: IP
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C-terminus of Human Keratin 12 protein (Q99456).

  • 阳性对照
    • Rat eyeball lysate.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

应用

Our Abpromise guarantee covers the use of ab124975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
  • 应用说明
    Is unsuitable for IP.
  • 靶标

    • 功能
      May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity.
    • 组织特异性
      Cornea specific.
    • 疾病相关
      Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
    • 序列相似性
      Belongs to the intermediate filament family.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CK-12 antibody
      • Cytokeratin-12 antibody
      • K12 antibody
      • K1C12_HUMAN antibody
      • Keratin 12 antibody
      • Keratin antibody
      • Keratin, type I cytoskeletal 12 antibody
      • Keratin-12 antibody
      • KRT12 antibody
      • type I cytoskeletal 12 antibody
      see all

    Anti-Keratin 12 antibody [EPR1609(2)] 图像

    • Anti-Keratin 12 antibody [EPR1609(2)] (ab124975) at 1/1000 dilution + Rat eyeball lysate at 10 µg

      Predicted band size : 54 kDa

    实验方案

    Anti-Keratin 12 antibody [EPR1609(2)] (ab124975)参考文献

    This product has been referenced in:
    • Li G  et al. Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease. J Biol Chem 290:20448-54 (2015). Read more (PubMed: 26045558) »
    • Ouyang H  et al. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature 511:358-61 (2014). Read more (PubMed: 25030175) »

    See all 2 Publications for this product

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