Anti-Keratin 12抗体(ab113039)

概述

  • 产品名称Anti-Keratin 12抗体
    参阅全部 Keratin 12 一抗
  • 描述
    兔多克隆抗体to Keratin 12
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide from a region between amino acids 449-479 from the C-terminal region of Human Keratin 12 (NP_000214.1).

  • 阳性对照
    • K562 cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab113039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 54 kDa.

靶标

  • 功能May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity.
  • 组织特异性Cornea specific.
  • 疾病相关Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD) [MIM:122100]; also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
  • 序列相似性Belongs to the intermediate filament family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CK-12 antibody
    • Cytokeratin-12 antibody
    • K12 antibody
    • K1C12_HUMAN antibody
    • Keratin 12 antibody
    • Keratin antibody
    • Keratin, type I cytoskeletal 12 antibody
    • Keratin-12 antibody
    • KRT12 antibody
    • type I cytoskeletal 12 antibody
    see all

Anti-Keratin 12 antibody 图像

  • Anti-Keratin 12 antibody (ab113039) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 54 kDa

Anti-Keratin 12 antibody (ab113039)参考文献

ab113039 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113039.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"