KDM4/JMJD2 Activity Quantification Assay试剂盒(Fluorometric) (ab113462)

概述

  • 产品名称KDM4/JMJD2 Activity Quantification Assay试剂盒(Fluorometric)
    参阅全部 KDM4/JMJD2 试剂盒
  • 检测类型Enzyme activity
  • 检测时间
    3h 00m
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: all Mammals
  • 产品概述

    KDM4/JMJD2 (Lysine-specific demethylase 4) is a family of histone demethyltransferases involved in H3(meK9) specific demethylation. The KDM4/JMJD2 family are JmjC proteins that specifically removes tri-methylation from H3(meK9) and H3(meK36) but has no activity on mono- or di-methylated residues.

    Abcam's KDM4/JMJD2 Activity Quantification Assay Kit (Fluorometric) (ab113462) is designed for the easy and fast fluorometric measurement of KDM4/JMJD2 activity or inhibition. The antibody-based, immunospecific method directly detects KDM4/JMJD2-converted demethylated products, rather than by-products, in a 96 stripwell microplate format.

  • 说明

     

     

  • 经测试应用适用于: Functional Studiesmore details

性能

    应用

    Our Abpromise guarantee covers the use of ab113462 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    KDM4/JMJD2 Activity Quantification Assay Kit (Fluorometric) 图像

    • Demonstration of high sensitivity of the KDM4/JMJD2 activity assay achieved by using recombinant KDM4/JMJD2 with ab113462.

    实验方案

    KDM4/JMJD2 Activity Quantification Assay Kit (Fluorometric) (ab113462)参考文献

    This product has been referenced in:
    • Jin C  et al. Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens. Proc Natl Acad Sci U S A 111:9235-40 (2014). Read more (PubMed: 24928520) »

    See 1 Publication for this product

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