Anti-KDM4B / JMJD2B (phospho T305)抗体(ab103410)

概述

  • 产品名称
    Anti-KDM4B / JMJD2B (phospho T305)抗体
    参阅全部 KDM4B / JMJD2B 一抗
  • 描述
    兔多克隆抗体to KDM4B / JMJD2B (phospho T305)
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Human KDM4B/ JMJD2B aa 281-306 (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: O94953

  • 阳性对照
    • MDA-MB435 and NIH 3T3 cell line lysates

性能

应用

Our Abpromise guarantee covers the use of ab103410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 122 kDa.

靶标

  • 功能
    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
  • 序列相似性
    Belongs to the JHDM3 histone demethylase family.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 2 PHD-type zinc fingers.
    Contains 2 Tudor domains.
  • 结构域
    The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • JHDM3B antibody
    • JmjC domain-containing histone demethylation protein 3B antibody
    • JMJD2B antibody
    • Jumonji domain containing 2B antibody
    • Jumonji domain containing protein 2B antibody
    • Jumonji domain-containing protein 2B antibody
    • Kdm4b antibody
    • KDM4B_HUMAN antibody
    • KIAA0876 antibody
    • Lysine (K) specific demethylase 4B antibody
    • Lysine demethylase 4B antibody
    • Lysine-specific demethylase 4B antibody
    • TDRD14B antibody
    • Tudor domain containing 14B antibody
    see all

图片

  • Anti-KDM4B / JMJD2B (phospho T305) antibody (ab103410) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size : 122 kDa
  • Anti-KDM4B / JMJD2B (phospho T305) antibody (ab103410) at 1/100 dilution + NIH 3T3 cell line lysates at 35 µg

    Predicted band size : 122 kDa

实验方案

文献

ab103410 has not yet been referenced specifically in any publications.

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