Anti-KDM4B / JMJD2B抗体(ab80473)

概述

  • 产品名称Anti-KDM4B / JMJD2B抗体
    参阅全部 KDM4B / JMJD2B 一抗
  • 描述
    兔多克隆抗体to KDM4B / JMJD2B
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residue 625 and 675 of Human KDM4B/ JMJD2B (NP_055830.1)

  • 阳性对照
    • Whole cell lysate from HeLa cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab80473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
    • 序列相似性Belongs to the JHDM3 histone demethylase family.
      Contains 1 JmjC domain.
      Contains 1 JmjN domain.
      Contains 2 PHD-type zinc fingers.
      Contains 2 Tudor domains.
    • 结构域The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • JHDM3B antibody
      • JmjC domain-containing histone demethylation protein 3B antibody
      • JMJD2B antibody
      • Jumonji domain containing protein 2B antibody
      • Jumonji domain-containing protein 2B antibody
      • Kdm4b antibody
      • KDM4B_HUMAN antibody
      • KIAA0876 antibody
      • Lysine-specific demethylase 4B antibody
      see all

    Anti-KDM4B / JMJD2B antibody (ab80473)参考文献

    ab80473 has not yet been referenced specifically in any publications.

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    In regards to the homology observed between the sequence provided and the immunogen used to raise the antibodies mentioned, the highest percentage corresponds to ab91549, which shares 75% of the sequence.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"