概述

  • 产品名称Anti-KCTD11抗体
    参阅全部 KCTD11 一抗
  • 描述
    山羊多克隆抗体to KCTD11
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    PEVEYGRLGLQP

    by a Cysteine residue linker, corresponding to internal sequence amino acids 167-178 of Human KCTD11 (NP_001002914.1).

  • 阳性对照
    • HEK293 lysate overexpressing Human KCTD11.

性能

应用

Our Abpromise guarantee covers the use of ab113423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 26 kDa). Primary incubation time: 1 hour.

靶标

  • 相关性The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.
  • 数据库链接
  • 别名
    • C 17 orf 36 antibody
    • C17orf36 antibody
    • MGC 129844 antibody
    • Potassium channel tetramerisation domain containing 11 antibody
    • REN antibody
    • Retinoic acid EGF NGF induced gene protein antibody
    see all

Anti-KCTD11 antibody 图像

  • Lane 1 : Anti-KCTD11 antibody (ab113423) at 1 µg/ml
    Lane 2 : Anti-KCTD11 antibody (ab113423) at 1 mg/ml
    Lane 3 : anti-DYKDDDDK Tag at 1/5000 dilution

    Lane 1 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag at 10 µg
    Lane 2 : HEK293 lysate, Mock-transfected
    Lane 3 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag at 10 µg

    Developed using the ECL technique

    Predicted band size : 26 kDa

Anti-KCTD11 antibody (ab113423)参考文献

ab113423 has not yet been referenced specifically in any publications.

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