概述

  • 产品名称
  • 描述
    兔多克隆抗体to KCNV2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region from N terminal amino acids 36-85 (

    RSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAGEVTTAK

    ) of Human KCNV2 (NP_598004).

  • 阳性对照
    • 293T Cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab85595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
  • 组织特异性
    Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.
  • 疾病相关
    Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.
  • 序列相似性
    Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.
  • 结构域
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 细胞定位
    Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KCNV2 antibody
    • KCNV2_HUMAN antibody
    • KV11.1 antibody
    • Kv8.2 antibody
    • MGC120515 antibody
    • Potassium channel subfamily V member 2 antibody
    • Potassium voltage-gated channel subfamily V member 2 antibody
    • RCD3B antibody
    • Voltage-gated potassium channel Kv8.2 antibody
    • Voltage-gated potassium channel subunit Kv8.2 antibody
    see all

图片

  • Anti-KCNV2 antibody (ab85595) at 1 µg/ml (in 5% skim milk / PBS buffer) + 293T Cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 62 kDa
    Observed band size : 62 kDa

实验方案

文献

ab85595 has not yet been referenced specifically in any publications.

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