概述

  • 产品名称Anti-KCNV2抗体
    参阅全部 KCNV2 一抗
  • 描述
    兔多克隆抗体to KCNV2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from internal sequence of Human KCNV2.

  • 阳性对照
    • Extracts from MCF-7 cells

性能

应用

Our Abpromise guarantee covers the use of ab110397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 62 kDa.

靶标

  • 功能Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
  • 组织特异性Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.
  • 疾病相关Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.
  • 序列相似性Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.
  • 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 细胞定位Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KCNV2 antibody
    • KCNV2_HUMAN antibody
    • KV11.1 antibody
    • Kv8.2 antibody
    • MGC120515 antibody
    • Potassium channel subfamily V member 2 antibody
    • Potassium voltage-gated channel subfamily V member 2 antibody
    • RCD3B antibody
    • Voltage-gated potassium channel Kv8.2 antibody
    • Voltage-gated potassium channel subunit Kv8.2 antibody
    see all

Anti-KCNV2 antibody 图像

  • All lanes : Anti-KCNV2 antibody (ab110397) at 1/500 dilution

    Lane 1 : Extracts from MCF-7 cells
    Lane 2 : Extracts from MCF-7 cells with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 62 kDa

Anti-KCNV2 antibody (ab110397)参考文献

ab110397 has not yet been referenced specifically in any publications.

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