Anti-KCNU1抗体[N2/16] (ab94586)

概述

  • 产品名称
    Anti-KCNU1抗体[N2/16]
  • 描述
    小鼠单克隆抗体[N2/16] to KCNU1
  • 宿主
    Mouse
  • 经测试应用
    适用于: WB, IHC-P, IHC-Fr, ICC/IFmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Fusion protein: DSSPSIQAQN NSTNATTPLA QGSNFFDSHH ADESHDLYPV DDTGERWSQH HHSRVYPLDT LDASDIVQEK, corresponding to amino acids 1052-1121 of Mouse KCNU1 (AAB99742).

  • 阳性对照
    • Mouse brain lysate
  • 常规说明

    The clone number has been updated from S2-16 to N2/16, both clone numbers name the same antibody clone.

     

性能

应用

Our Abpromise guarantee covers the use of ab94586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 130 kDa.
IHC-P Use a concentration of 0.1 - 1 µg/ml.

Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).

IHC-Fr Use a concentration of 0.1 - 1 µg/ml.

Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).

ICC/IF Use a concentration of 1 - 10 µg/ml.

Use at a concentration of 0.1-1.0µg/mL (perox) or 1.0-10µg/mL (IF).

靶标

  • 功能
    Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.
  • 组织特异性
    Testis-specific.
  • 序列相似性
    Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.
    Contains 1 RCK N-terminal domain.
  • 结构域
    The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
    The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium.
    The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel.
    The C-terminal cytosolic region confers the pH-dependence.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • subfamily M subunit alpha-3 antibody
    • Calcium activated potassium channel subfamily M subunit alpha 3 antibody
    • Calcium activated potassium channel subunit alpha 3 antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit alpha-3 antibody
    • KCa5 antibody
    • KCa5.1 antibody
    • Kcnma3 antibody
    • KCNMC1 antibody
    • KCNU 1 antibody
    • KCNU1 antibody
    • KCNU1_HUMAN antibody
    • Potassium channel subfamily U member 1 antibody
    • Slo3 antibody
    • Slowpoke homolog 3 antibody
    see all

图片

  • Western blot detection of KCNU1 in Rat brain membrane lysates using ab94586 at 1:1000 dilution.

文献

ab94586 has not yet been referenced specifically in any publications.

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