Anti-KCNQ5抗体- Carboxyterminal end (ab66740)

概述

  • 产品名称Anti-KCNQ5抗体- Carboxyterminal end
    参阅全部 KCNQ5 一抗
  • 描述
    兔多克隆抗体to KCNQ5 - Carboxyterminal end
  • 经测试应用适用于: WB, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from the C terminal domain of KCNQ5 (Human)

性能

应用

Our Abpromise guarantee covers the use of ab66740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/5000. Predicted molecular weight: 99 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
  • 组织特异性Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
  • 序列相似性Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
  • 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KCNQ 5 antibody
    • KCNQ5 antibody
    • KCNQ5_HUMAN antibody
    • KQT like 5 antibody
    • KQT-like 5 antibody
    • Kv7.5 antibody
    • OTTHUMP00000064152 antibody
    • OTTHUMP00000064153 antibody
    • Potassium channel alpha subunit KvLQT5 antibody
    • Potassium channel protein antibody
    • Potassium channel subunit alpha KvLQT5 antibody
    • Potassium voltage gated channel KQT like subfamily member 5 antibody
    • Potassium voltage gated channel subfamily KQT member 5 antibody
    • Potassium voltage-gated channel subfamily KQT member 5 antibody
    • Voltage gated potassium channel subunit Kv7.5 antibody
    • Voltage-gated potassium channel subunit Kv7.5 antibody
    see all

Anti-KCNQ5 antibody - Carboxyterminal end (ab66740)参考文献

ab66740 has not yet been referenced specifically in any publications.

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