概述

  • 产品名称
  • 描述
    兔多克隆抗体to KCNQ5
  • 特异性
    ab19319 detects the KCNQ5 from rat samples. This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.
  • 经测试应用
    适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Synthetic peptide:

    CKAGESTDALSLPHVKLK

    , corresponding to amino acids 880-897 of Rat KCNQ5.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.05% Sodium Azide
    Constituents: PBS, 1mg/ml BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab19319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/250. Detects a band of approximately 116 kDa.

靶标

  • 功能
    Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
  • 组织特异性
    Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
  • 序列相似性
    Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
  • 结构域
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KCNQ 5 antibody
    • KCNQ5 antibody
    • KCNQ5_HUMAN antibody
    • KQT like 5 antibody
    • KQT-like 5 antibody
    • Kv7.5 antibody
    • OTTHUMP00000064152 antibody
    • OTTHUMP00000064153 antibody
    • Potassium channel alpha subunit KvLQT5 antibody
    • Potassium channel protein antibody
    • Potassium channel subunit alpha KvLQT5 antibody
    • Potassium voltage gated channel KQT like subfamily member 5 antibody
    • Potassium voltage gated channel subfamily KQT member 5 antibody
    • Potassium voltage-gated channel subfamily KQT member 5 antibody
    • Voltage gated potassium channel subunit Kv7.5 antibody
    • Voltage-gated potassium channel subunit Kv7.5 antibody
    see all

Anti-KCNQ5 antibody (ab19319)参考文献

ab19319 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab19319.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册