概述

  • 产品名称Anti-KCNQ4抗体
    参阅全部 KCNQ4 一抗
  • 描述
    山羊多克隆抗体to KCNQ4
  • 特异性ab82096 is expected to recognise both reported isoforms (NP_004691.2; NP_751895.1).
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-DKGPSDAEVVDE

    , corresponding to internal sequence amino acids 601-612 of Human KCNQ4 (NP_004691.2).

  • 阳性对照
    • Human Brain (Cerebellum) lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab82096 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab82096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/4000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 77 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors.
    • 组织特异性Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
    • 疾病相关Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A) [MIM:600101]. DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    • 序列相似性Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily.
    • 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
      The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four-stranded.
    • 细胞定位Basal cell membrane. Situated at the basal membrane of cochlear outer hair cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DFNA 2 antibody
      • DFNA2 antibody
      • KCNQ 4 antibody
      • Kcnq4 antibody
      • KCNQ4_HUMAN antibody
      • KQT like 4 antibody
      • KQT-like 4 antibody
      • KV7.4 antibody
      • Potassium channel KQT like 4 antibody
      • Potassium channel subunit alpha KvLQT4 antibody
      • Potassium voltage gated channel KQT like protein 4 antibody
      • Potassium voltage gated channel KQT like subfamily member 4 antibody
      • Potassium voltage gated channel subfamily KQT member 4 antibody
      • Potassium voltage-gated channel subfamily KQT member 4 antibody
      • Voltage gated potassium channel subunit Kv7.4 antibody
      • Voltage-gated potassium channel subunit Kv7.4 antibody
      see all

    Anti-KCNQ4 antibody 图像

    • Anti-KCNQ4 antibody (ab82096) at 2 µg/ml + Human Cerebellum lysate (in RIPA buffer). at 35 µg
      Developed using the ECL technique

      Predicted band size : 77 kDa
      Observed band size : 70 kDa (why is the actual band size different from the predicted?)

    Anti-KCNQ4 antibody (ab82096)参考文献

    ab82096 has not yet been referenced specifically in any publications.

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