概述

  • 产品名称
  • 描述
    兔多克隆抗体to KCNQ3
  • 特异性
    This antibody is specific for KCNQ3 and does not detect KCNQ1, KCNQ2, KCNQ4 or KCNQ5.
  • 经测试应用
    适用于: ICC/IF, ICC, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment (proprietary-tag) corresponding to Rat KCNQ3 aa 1-71 (N terminal).

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: PBS, 1mg/ml BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab16228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
ICC
IHC-Fr
  • 应用说明
    ICC: Use at a concentration of 0.5 µg/ml.
    IF: Use at a concentration of 0.5 µg/ml.
    IHC-Fr: Use at a concentration of 0.5 µg/ml. This antibody gives a strong signal mainly in interneurons and astrocytes in the dentate region of rat hippocampal samples.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
    • 组织特异性
      Predominantly expressed in brain.
    • 疾病相关
      Defects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset.
    • 序列相似性
      Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
    • 结构域
      The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BFNC 2 antibody
      • BFNC antibody
      • BFNC2 antibody
      • EBN 2 antibody
      • EBN2 antibody
      • KCNQ 3 antibody
      • KCNQ3 antibody
      • KCNQ3_HUMAN antibody
      • KQT like 3 antibody
      • KQT-like 3 antibody
      • KV7.3 antibody
      • Potassium channel subunit alpha KvLQT3 antibody
      • Potassium channel voltage gated subfamily Q member 3 antibody
      • Potassium voltage gated channel KQT like protein 3 antibody
      • Potassium voltage gated channel KQT like subfamily member 3 antibody
      • Potassium voltage gated channel subfamily KQT member 3 antibody
      • Potassium voltage-gated channel subfamily KQT member 3 antibody
      • Voltage gated potassium channel subunit Kv7.3 antibody
      • Voltage-gated potassium channel subunit Kv7.3 antibody
      see all

    Anti-KCNQ3 antibody (ab16228)参考文献

    ab16228 has not yet been referenced specifically in any publications.

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