Anti-KCNQ2抗体(ab28778)

概述

  • 产品名称Anti-KCNQ2抗体
    参阅全部 KCNQ2 一抗
  • 描述
    兔多克隆抗体to KCNQ2
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Drosophila melanogaster, Zebrafish
  • 免疫原

    A region within a synthetic peptide: AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK, corresponding to internal sequence amino acids 181-230 of Human KCNQ2

  • 阳性对照
    • HepG2 cells lysate for WB, human kidney tissue for IHC-P.

性能

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应用

Our Abpromise guarantee covers the use of ab28778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/62500.
WB Use a concentration of 1.25 µg/ml. Predicted molecular weight: 98 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
  • 组织特异性In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.
  • 疾病相关Defects in KCNQ2 are the cause of benign familial neonatal seizures type 1 (BFNS1) [MIM:121200]. A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Some patients may have isolated myokymia.
    Defects in KCNQ2 are the cause of epileptic encephalopathy early infantile type 7 (EIEE7) [MIM:613720]. EIEE7 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities.
  • 序列相似性Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily.
  • 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 翻译后修饰In Xenopus oocytes KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminus region.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BFNC antibody
    • BFNS1 antibody
    • EBN 1 antibody
    • EBN antibody
    • EBN1 antibody
    • EIEE7 antibody
    • ENB 1 antibody
    • ENB1 antibody
    • HNSPC antibody
    • KCNA 11 antibody
    • KCNA11 antibody
    • KCNQ 2 antibody
    • Kcnq2 antibody
    • KCNQ2_HUMAN antibody
    • KQT like 2 antibody
    • KQT-like 2 antibody
    • KV7.2 antibody
    • KVEBN 1 antibody
    • KVEBN1 antibody
    • KvLQT 2 antibody
    • KvLQT2 antibody
    • Neuroblastoma specific potassium channel alpha subunit KvLQT2 antibody
    • Neuroblastoma specific potassium channel protein antibody
    • Neuroblastoma specific potassium channel subunit alpha antibody
    • Neuroblastoma specific potassium channel subunit alpha KvLQT2 antibody
    • Neuroblastoma-specific potassium channel subunit alpha KvLQT2 antibody
    • OTTHUMP00000031681 antibody
    • OTTHUMP00000031682 antibody
    • OTTHUMP00000031684 antibody
    • OTTHUMP00000031685 antibody
    • OTTHUMP00000031686 antibody
    • OTTHUMP00000031687 antibody
    • OTTHUMP00000031689 antibody
    • Potassium voltage gated channel KQT like protein 2 antibody
    • Potassium voltage gated channel KQT like subfamily member 2 antibody
    • Potassium voltage gated channel subfamily KQT member 2 antibody
    • Potassium voltage-gated channel subfamily KQT member 2 antibody
    • Voltage gated potassium channel subunit Kv7.2 antibody
    • Voltage-gated potassium channel subunit Kv7.2 antibody
    see all

Anti-KCNQ2 antibody 图像

  • Anti-KCNQ2 antibody (ab28778) at 1.25 µg/ml + HepG2 cell lysate

    Predicted band size : 98 kDa
    Observed band size : 43 kDa (why is the actual band size different from the predicted?)
  • Ab28778, at a concentration of 4.0-8.0 µg/ml, staining KCNQ2 in paraffin embedded human epithelial cells of renal tubule by Immunohistochemistry.
    Magnification: 400x.
    Ab28778, at a concentration of 4.0-8.0 µg/ml, staining KCNQ2 in paraffin embedded human epithelial cells of renal tubule by Immunohistochemistry.
    Magnification: 400x.

Anti-KCNQ2 antibody (ab28778)参考文献

ab28778 has not yet been referenced specifically in any publications.

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I am sorry to confirm that as far as we are aware, ab28778 and ab105511 KCNQ2 antibodies have never been tested in IP. All tested applications covered by the 6 month guarante...

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