Anti-KCNMB4抗体[S18A-3] (ab105587)

概述

  • 产品名称Anti-KCNMB4抗体[S18A-3]
    参阅全部 KCNMB4 一抗
  • 描述
    小鼠单克隆抗体[S18A-3] to KCNMB4
  • 特异性ab105587 shows no cross-reactivity against BKBeta1, BKBeta2 or BKBeta3.
  • 经测试应用适用于: WB, IHC-P, IHC-Fr, ICC, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Fusion protein, corresponding to extracellular amino acids 45 - 167 of Mouse KCNMB4 (NP_067427).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号S18A-3
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab105587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. 1 µg/mL of ab105587 was sufficient for detection of KCNMB4 in 10µg of COS-1 cells transiently transfected with KCNMB4 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
IHC-P Use a concentration of 0.1 - 1 µg/ml.
IHC-Fr Use a concentration of 0.1 - 1 µg/ml.
ICC Use a concentration of 0.1 - 1 µg/ml.
ICC/IF Use a concentration of 1 - 10 µg/ml.

靶标

  • 功能Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
  • 组织特异性Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
  • 序列相似性Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.
  • 结构域Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.
  • 翻译后修饰Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
    N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BK channel subunit beta 4 antibody
    • BK channel subunit beta-4 antibody
    • BKbeta4 antibody
    • Calcium activated potassium channel beta 4 subunit antibody
    • Calcium activated potassium channel subfamily M subunit beta 4 antibody
    • Calcium activated potassium channel subunit beta 4 antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit beta-4 antibody
    • Charybdotoxin receptor subunit beta 4 antibody
    • Charybdotoxin receptor subunit beta-4 antibody
    • Hbeta4 antibody
    • K(VCA)beta 4 antibody
    • K(VCA)beta-4 antibody
    • KCMB4_HUMAN antibody
    • KCNMB 4 antibody
    • Kcnmb4 antibody
    • Large conductance calcium dependent potassium ion channel beta 4 subunit antibody
    • Maxi K channel subunit beta 4 antibody
    • Maxi K channel subunit beta-4 antibody
    • Potassium large conductance calcium activated channel subfamily M beta member 4 antibody
    • Slo beta 4 antibody
    • Slo-beta-4 antibody
    • subfamily M subunit beta-4 antibody
    see all

Anti-KCNMB4 antibody [S18A-3] 图像

  • Immunohistochemical of KCNMB4 in Brain tissues using a dilution of ab105587.

Anti-KCNMB4 antibody [S18A-3] (ab105587)参考文献

ab105587 has not yet been referenced specifically in any publications.

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