概述

  • 产品名称Anti-KCNMB4抗体
    参阅全部 KCNMB4 一抗
  • 描述
    兔多克隆抗体to KCNMB4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Guinea pig, Cow, Cat, Pig
  • 免疫原

    Synthetic peptide designed within residues: CGADCRGTSQ YPCVQVYVNN SESNSRALLH SDEHQLLTNP KCSYIPPCKR, corresponding to internal sequence amino acids 72-121 of Human KCNMB4 (NP_055320)

  • 阳性对照
    • THP1 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab89703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
  • 组织特异性Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.
  • 序列相似性Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.
  • 结构域Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.
  • 翻译后修饰Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
    N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BK channel subunit beta 4 antibody
    • BK channel subunit beta-4 antibody
    • BKbeta4 antibody
    • Calcium activated potassium channel beta 4 subunit antibody
    • Calcium activated potassium channel subfamily M subunit beta 4 antibody
    • Calcium activated potassium channel subunit beta 4 antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit beta-4 antibody
    • Charybdotoxin receptor subunit beta 4 antibody
    • Charybdotoxin receptor subunit beta-4 antibody
    • Hbeta4 antibody
    • K(VCA)beta 4 antibody
    • K(VCA)beta-4 antibody
    • KCMB4_HUMAN antibody
    • KCNMB 4 antibody
    • Kcnmb4 antibody
    • Large conductance calcium dependent potassium ion channel beta 4 subunit antibody
    • Maxi K channel subunit beta 4 antibody
    • Maxi K channel subunit beta-4 antibody
    • Potassium large conductance calcium activated channel subfamily M beta member 4 antibody
    • Slo beta 4 antibody
    • Slo-beta-4 antibody
    • subfamily M subunit beta-4 antibody
    see all

Anti-KCNMB4 antibody 图像

  • Anti-KCNMB4 antibody (ab89703) at 1 µg/ml + THP1 cell lysate at 10 µg

    Secondary
    HRP-conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa

Anti-KCNMB4 antibody (ab89703)参考文献

This product has been referenced in:
  • Yang J  et al. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. J Hematol Oncol 7:76 (2014). WB, IHC ; Human . Read more (PubMed: 25300797) »

See 1 Publication for this product

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