概述

  • 产品名称Anti-KCNMB3抗体
    参阅全部 KCNMB3 一抗
  • 描述
    小鼠单克隆抗体to KCNMB3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: FMLSIQREES TCTAIHTDIM DDWLDCAFTC GVHCHGQGKY PCLQVFVNLS HPGQKALLHY NEEAVQINPK CFYTPKCHQD RNDLLNSALD IKEFFDHKNG , corresponding to amino acids 82-182 of Human KCNMB3

性能

应用

Our Abpromise guarantee covers the use of ab57219 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
    • 组织特异性Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
    • 序列相似性Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
    • 结构域Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site.
      The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.
    • 翻译后修饰N-glycosylated.
      The extracellular domain contains disulfide bond essential for the gating mechanism.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BK channel subunit beta 3 antibody
      • BK channel subunit beta-3 antibody
      • BKbeta 3 antibody
      • BKbeta3 antibody
      • Calcium activated potassium channel beta 3 subunit antibody
      • Calcium activated potassium channel subfamily M subunit beta 3 antibody
      • Calcium activated potassium channel subunit beta 3 antibody
      • Calcium-activated potassium channel antibody
      • Calcium-activated potassium channel subunit beta-3 antibody
      • Charybdotoxin receptor subunit beta 3 antibody
      • Charybdotoxin receptor subunit beta-3 antibody
      • EG435726 antibody
      • Gm5707 antibody
      • Hbeta 3 antibody
      • Hbeta3 antibody
      • K(VCA)beta 3 antibody
      • K(VCA)beta-3 antibody
      • KCMB3_HUMAN antibody
      • KCNMB 2 antibody
      • KCNMB 3 antibody
      • KCNMB2 antibody
      • KCNMB3 antibody
      • KCNMBL antibody
      • Large conductance voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit antibody
      • Maxi K channel subunit beta 3 antibody
      • Maxi K channel subunit beta-3 antibody
      • Potassium channel, calcium-activated large conductance, subfamily M, beta member 3 antibody
      • Potassium large conductance calcium activated channel beta 3 subunit antibody
      • Potassium large conductance calcium activated channel subfamily M beta member 3 antibody
      • Slo beta 3 antibody
      • Slo-beta-3 antibody
      • subfamily M subunit beta-3 antibody
      see all

    Anti-KCNMB3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57219 KCNMB3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-KCNMB3 antibody (ab57219)参考文献

    ab57219 has not yet been referenced specifically in any publications.

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