• 产品名称Anti-KCNK18/TRESK抗体
    参阅全部 KCNK18/TRESK 一抗
  • 描述
    兔多克隆抗体to KCNK18/TRESK
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    KLH conjugated synthetic peptide derived from internal sequence of Human KCNK18/TRESK.

  • 阳性对照
    • Human Heart tissue; Rat brain tissue lysate.



Our Abpromise guarantee covers the use of ab113883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 44 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.


  • 功能Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.
  • 组织特异性Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.
  • 疾病相关Defects in KCNK18 are a cause of migraine with or without aura type 13 (MGR13) [MIM:613656]. A form of migraine trasmitted in an autosomal dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. Note=Susceptibility to migraine has been shown to be conferred by a frameshift mutation that segregates with the disorder in a large multigenerational family. Migraine was associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional vomiting. Triggers included fatigue, alcohol and bright lights. Mutations in KCNK18 are a rare cause of migraine.
  • 序列相似性Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • 翻译后修饰Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • K2p18.1 antibody
    • KCNK18 antibody
    • KCNKI_HUMAN antibody
    • MGR13 antibody
    • OTTHUMP00000020575 antibody
    • Potassium channel subfamily K member 18 antibody
    • TRESK 2 antibody
    • TRESK antibody
    • TRESK2 antibody
    • TRIK antibody
    • TWIK related individual K+ channel antibody
    • TWIK related individual potassium channel antibody
    • TWIK related spinal cord K+ channel antibody
    • TWIK related spinal cord potassium channel antibody
    • TWIK-related individual potassium channel antibody
    • TWIK-related spinal cord potassium channel antibody
    see all

Anti-KCNK18/TRESK antibody 图像

  • ab113883, at 5 µg/ml, staining KCNK18/TRESK in formalin-fixed, paraffin-embedded Human heart tissue by Immunohistochemistry.
  • Lane 1 : Anti-KCNK18/TRESK antibody (ab113883) at 1 µg/ml
    Lane 2 : Anti-KCNK18/TRESK antibody (ab113883) at 2 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate

    Predicted band size : 44 kDa

Anti-KCNK18/TRESK antibody (ab113883)参考文献

ab113883 has not yet been referenced specifically in any publications.

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