• 产品名称Anti-KCNK18/TRESK抗体
    参阅全部 KCNK18/TRESK 一抗
  • 描述
    兔多克隆抗体to KCNK18/TRESK
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 17 amino acid peptide from near the center of Human KCNK18/TRESK (NP_862823).

  • 阳性对照
    • Rat brain tissue IF: SKNSH cell line



Our Abpromise guarantee covers the use of ab106411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 44 kDa.
IHC-P Use a concentration of 5 µg/ml.
ICC/IF Use a concentration of 5 µg/ml.


  • 功能Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.
  • 组织特异性Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.
  • 疾病相关Defects in KCNK18 are a cause of migraine with or without aura type 13 (MGR13) [MIM:613656]. A form of migraine trasmitted in an autosomal dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. Note=Susceptibility to migraine has been shown to be conferred by a frameshift mutation that segregates with the disorder in a large multigenerational family. Migraine was associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional vomiting. Triggers included fatigue, alcohol and bright lights. Mutations in KCNK18 are a rare cause of migraine.
  • 序列相似性Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • 翻译后修饰Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • K2p18.1 antibody
    • KCNK18 antibody
    • KCNKI_HUMAN antibody
    • MGR13 antibody
    • OTTHUMP00000020575 antibody
    • Potassium channel subfamily K member 18 antibody
    • TRESK 2 antibody
    • TRESK antibody
    • TRESK2 antibody
    • TRIK antibody
    • TWIK related individual K+ channel antibody
    • TWIK related individual potassium channel antibody
    • TWIK related spinal cord K+ channel antibody
    • TWIK related spinal cord potassium channel antibody
    • TWIK-related individual potassium channel antibody
    • TWIK-related spinal cord potassium channel antibody
    see all

Anti-KCNK18/TRESK antibody 图像

  • Lane 1 : Anti-KCNK18/TRESK antibody (ab106411) at 1 µg/ml
    Lane 2 : Anti-KCNK18/TRESK antibody (ab106411) at 2 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size : 44 kDa
  • ab106411, at 5 µg/ml, staining KCNK18/TRESK in paraffin embedded Rat brain tissue.
  • ICC/IF image of ab106411 stained SKNSH cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab106411, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
  • Immunofluorescence of TRESK in Rat Brain cells using ab106411 at 20 ug/ml.

Anti-KCNK18/TRESK antibody (ab106411)参考文献

ab106411 has not yet been referenced specifically in any publications.

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