概述

  • 产品名称Anti-KCNJ5抗体
    参阅全部 KCNJ5 一抗
  • 描述
    兔多克隆抗体to KCNJ5
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from the C-terminal of human KCNJ5.

  • 阳性对照
    • Extracts from HeLa cells. A549 cells.

性能

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应用

Our Abpromise guarantee covers the use of ab75238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 48 kDa.
ELISA 1/5000.
ICC/IF 1/500 - 1/1000.

靶标

  • 功能This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
  • 组织特异性Islets, exocrine pancreas and heart.
  • 疾病相关Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13) [MIM:613485]. It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
  • 序列相似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cardiac ATP sensitive potassium channel antibody
    • Cardiac inward rectifier antibody
    • CIR antibody
    • G protein activated inward rectifier potassium channel 4 antibody
    • G protein-activated inward rectifier potassium channel 4 antibody
    • GIRK 4 antibody
    • GIRK-4 antibody
    • GIRK4 antibody
    • Heart KATP channel antibody
    • Inward rectifier K(+) channel Kir3.4 antibody
    • Inward rectifier K+ channel KIR3.4 antibody
    • inwardly rectifying subfamily J member 5 antibody
    • IRK-4 antibody
    • IRK5_HUMAN antibody
    • KATP 1 antibody
    • KATP-1 antibody
    • KATP1 antibody
    • KCNJ 5 antibody
    • Kcnj5 antibody
    • KIR 3.4 antibody
    • KIR3.4 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 5 antibody
    • Potassium inwardly rectifying channel J5 antibody
    • Potassium inwardly rectifying channel subfamily J member 5 antibody
    see all

Anti-KCNJ5 antibody 图像

  • All lanes : Anti-KCNJ5 antibody (ab75238) at 1/500 dilution

    Lane 1 : Extracts from HeLa cells
    Lane 2 : Extracts from HeLa cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 48 kDa
  • Immunofluorescence analysis of KCNJ5 in A549 cells using ab75238 at 1/500 dilution in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-KCNJ5 antibody (ab75238)参考文献

This product has been referenced in:
  • Molina-Navarro MM  et al. Differential gene expression of cardiac ion channels in human dilated cardiomyopathy. PLoS One 8:e79792 (2013). Human . Read more (PubMed: 24339868) »

See 1 Publication for this product

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