概述

  • 产品名称Anti-KCNJ1抗体
    参阅全部 KCNJ1 一抗
  • 描述
    兔多克隆抗体to KCNJ1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 216-265 (LRKSLLIGSH IYGKLLKTTV TPEGETIILD QININFVVDA GNENLFFISP) of Human KCNJ1 (NP_000211).

  • 阳性对照
    • HepG2 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab85479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
  • 组织特异性In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
  • 疾病相关Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 序列相似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ATP regulated potassium channel ROM K antibody
    • ATP sensitive inward rectifier potassium channel 1 antibody
    • ATP-regulated potassium channel ROM-K antibody
    • ATP-sensitive inward rectifier potassium channel 1 antibody
    • Inward rectifier K(+) channel Kir1.1 antibody
    • inwardly rectifying K+ channel antibody
    • inwardly rectifying subfamily J member 1 antibody
    • IRK1_HUMAN antibody
    • KCNJ 1 antibody
    • KCNJ antibody
    • Kcnj1 antibody
    • Kir 1.1 antibody
    • Kir1.1 antibody
    • OTTHUMP00000045938 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 1 antibody
    • potassium inwardly-rectifying channel J1 antibody
    • ROMK 1 antibody
    • ROMK 2 antibody
    • ROMK antibody
    • ROMK1 antibody
    • ROMK2 antibody
    see all

Anti-KCNJ1 antibody 图像

  • Anti-KCNJ1 antibody (ab85479) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 45 kDa

Anti-KCNJ1 antibody (ab85479)参考文献

ab85479 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab85479.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"