概述

  • 产品名称Anti-KCNC3抗体
    参阅全部 KCNC3 一抗
  • 描述
    山羊多克隆抗体to KCNC3
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit
  • 免疫原

    Synthetic peptide:

    C-KPGPPSFLPDLNAN

    , corresponding to C terminal amino acids 737-750 of Human KCNC3

  • 阳性对照
    • Human Brain (Frontal Cortex) lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab60170 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1/32000.

    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 81 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    • 疾病相关Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.
    • 序列相似性Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
    • 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
      The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Kcnc3 antibody
      • KCNC3_HUMAN antibody
      • KSHIIID antibody
      • KV3.3 antibody
      • Potassium voltage gated channel Shaw related subfamily member 3 antibody
      • Potassium voltage gated channel subfamily C member 3 antibody
      • Potassium voltage-gated channel subfamily C member 3 antibody
      • SCA13 antibody
      • Shaw related subfamily, member 3 antibody
      • Shaw related voltage gated potassium channel protein 3 antibody
      • Spinocerebellar ataxia 13 antibody
      • Voltage gated potassium channel protein KV3.3 antibody
      • Voltage gated potassium channel subunit Kv3.3 antibody
      • Voltage-gated potassium channel subunit Kv3.3 antibody
      see all

    Anti-KCNC3 antibody 图像

    Anti-KCNC3 antibody (ab60170)参考文献

    ab60170 has not yet been referenced specifically in any publications.

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