Anti-KCNC1 (phospho S503)抗体(ab30566)

概述

  • 产品名称
    Anti-KCNC1 (phospho S503)抗体
    参阅全部 KCNC1 一抗
  • 描述
    兔多克隆抗体to KCNC1 (phospho S503)
  • 特异性
    Specific for KCNC1 phosphorylated at S503.
  • 经测试应用
    适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Phosphopeptide corresponding to amino acid residues surrounding the phosphorylated S503 of rat KCNC1, conjugated to KLH (keyhole limpet haemocyanin).

  • 阳性对照
    • Rat brain

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES. pH 7.5
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from rabbit serum by sequential phospho- and dephosphopeptide affinity columns.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab30566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 100 kDa (predicted molecular weight: 66 kDa).
IHC-Fr 1/1000.

靶标

  • 功能
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
  • 疾病相关
    Epilepsy, progressive myoclonic 7
  • 序列相似性
    Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
  • 结构域
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C230009H10Rik antibody
    • FLJ41162 antibody
    • FLJ42249 antibody
    • FLJ43491 antibody
    • Kcnc1 antibody
    • KCNC1_HUMAN antibody
    • Kcr2 1 antibody
    • KShIIIB antibody
    • Kv3.1 antibody
    • Kv4 antibody
    • MGC129855 antibody
    • NGK2 antibody
    • Potassium voltage-gated channel subfamily C member 1 antibody
    • Shaw antibody
    • Voltage gated potassium channel antibody
    • Voltage gated potassium channel subunit Kv3.1 antibody
    • Voltage-gated potassium channel subunit Kv3.1 antibody
    • Voltage-gated potassium channel subunit Kv4 antibody
    see all

图片

  • Staining of rat medial nucleus of the trapezoid body (MNTB) cells with ab30566 (1/1000 dilution).
    Left - control cells. Right - cells that have been exposed to protein kinase C activator PMA.

文献

ab30566 has not yet been referenced specifically in any publications.

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