概述

  • 产品名称
    Anti-KCNC1抗体[N16B/8]
    参阅全部 KCNC1 一抗
  • 描述
    小鼠单克隆抗体[N16B/8] to KCNC1
  • 宿主
    Mouse
  • 特异性
    Weak cross reactivity with human.
  • 经测试应用
    适用于: IHC-Fr, IHC-P, WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Fusion protein, corresponding to cytoplasmic C terminal amino acids 437-585 of Rat KCNC1 (NP_036988).

  • 阳性对照
    • Rat brain lysate.
  • 常规说明

    The clone number has been updated from S16B-8 to N16B/8, both clone numbers name the same antibody clone.

     

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 50% Glycerol, PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    单克隆
  • 克隆编号
    N16B/8
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use a concentration of 0.1 - 1 µg/ml.
IHC-P Use a concentration of 0.1 - 1 µg/ml.
WB Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 58 kDa.
ICC/IF Use a concentration of 1 - 10 µg/ml.

靶标

  • 功能
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
  • 疾病相关
    Epilepsy, progressive myoclonic 7
  • 序列相似性
    Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
  • 结构域
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C230009H10Rik antibody
    • FLJ41162 antibody
    • FLJ42249 antibody
    • FLJ43491 antibody
    • Kcnc1 antibody
    • KCNC1_HUMAN antibody
    • Kcr2 1 antibody
    • KShIIIB antibody
    • Kv3.1 antibody
    • Kv4 antibody
    • MGC129855 antibody
    • NGK2 antibody
    • Potassium voltage-gated channel subfamily C member 1 antibody
    • Shaw antibody
    • Voltage gated potassium channel antibody
    • Voltage gated potassium channel subunit Kv3.1 antibody
    • Voltage-gated potassium channel subunit Kv3.1 antibody
    • Voltage-gated potassium channel subunit Kv4 antibody
    see all

图片

  • All lanes : Anti-KCNC1 antibody [N16B/8] (ab84823) at 1 µg/ml

    Lane 1 : Molecular weight marker
    Lane 2 : Tissue lysates prepared from rat brain

    Predicted band size: 58 kDa

文献

This product has been referenced in:
  • Uchino K  et al. Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression. Mol Ther 21:610-9 (2013). Read more (PubMed: 23295946) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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