概述

  • 产品名称Anti-KChIP2抗体
    参阅全部 KChIP2 一抗
  • 描述
    小鼠多克隆抗体to KChIP2
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Full length Human KChIP2 (NP_775283.1)

  • 阳性对照
    • Rat brain lysate with KChIP2 expression, KChIP2 transfected 293T cell lysate and HeLa cell.

性能

应用

Our Abpromise guarantee covers the use of ab88542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart.
  • 组织特异性Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
  • 序列相似性Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • 翻译后修饰Palmitoylated. Palmitoylation enhances association with the plasma membrane.
  • 细胞定位Cell membrane and Cell membrane. Detected on lipid rafts (By similarity).
  • Information by UniProt
  • 数据库链接
  • 形式There are 9 isoforms produced by alternative splicing.
  • 别名
    • A type potassium channel modulatory protein 2 antibody
    • A-type potassium channel modulatory protein 2 antibody
    • Cardiac voltage gated potassium channel modulatory subunit antibody
    • Cardiac voltage-gated potassium channel modulatory subunit antibody
    • DKFZp566L1246 antibody
    • KChIP 2 antibody
    • KChIP2 antibody
    • KCIP2_HUMAN antibody
    • KCNIP 2 antibody
    • Kcnip2 antibody
    • Kv channel interacting protein 2 antibody
    • Kv channel-interacting protein 2 antibody
    • MGC17241 antibody
    • Potassium channel interacting protein 2 antibody
    • Potassium channel-interacting protein 2 antibody
    see all

Anti-KChIP2 antibody 图像

  • Anti-KChIP2 antibody (ab88542) at 1 µg/ml + Rat brain lysate with KChIP2 expression at 50 µg

    Predicted band size : 31 kDa
    Observed band size : 31 kDa
  • All lanes : Anti-KChIP2 antibody (ab88542) at 1 µg/ml

    Lane 1 : KChIP2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 50 µg per lane.


    Predicted band size : 31 kDa
    Observed band size : 31 kDa
  • Immunofluorescence of ab88542 on HeLa cell with antibody concentration 10 ug/ml

Anti-KChIP2 antibody (ab88542)参考文献

ab88542 has not yet been referenced specifically in any publications.

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