概述

  • 产品名称Anti-KCC4抗体
    参阅全部 KCC4 一抗
  • 描述
    山羊多克隆抗体to KCC4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit
  • 免疫原

    Synthetic peptide:

    C-QLIHDRNTASHT

    , corresponding to internal sequence amino acids 951-962 of Human KCC4 (NP_006589.2).

性能

应用

Our Abpromise guarantee covers the use of ab78912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/2,000.
    WB: Preliminary experiments in Human Heart and Kidney lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification.
    • 组织特异性Detected in muscle, brain, lung, heart and kidney.
    • 序列相似性Belongs to the SLC12A transporter family.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • D13Ertd261e antibody
      • Electroneutral potassium-chloride cotransporter 4 antibody
      • Furosemide sensitive KCl cotransporter 4 antibody
      • K Cl cotransporter KCC4 antibody
      • K-Cl cotransporter 4 antibody
      • Potassium/chloride transporter KCC4 antibody
      • S12A7_HUMAN antibody
      • SLC12A7 antibody
      • Solute carrier family 12 (potassium/chloride transporters), member 7 antibody
      • Solute carrier family 12 member 7 antibody
      • Solute carrier family 12, member 7 antibody
      see all

    Anti-KCC4 antibody (ab78912)参考文献

    This product has been referenced in:
    • Sun Y  et al. A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain. J Proteomics 74:547-57 (2011). WB ; Human . Read more (PubMed: 21262400) »

    See 1 Publication for this product

    Product Wall

    Application Western blot
    Sample Mouse Tissue lysate - whole (Hippocampus)
    Loading amount 5 µg
    Specification Hippocampus
    Gel Running Conditions Reduced Denaturing (10%)
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Username

    Abcam user community

    Verified customer

    提交于 Sep 06 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"