Anti-KAT7 / Hbo1 / MYST2抗体(ab87100)

概述

  • 产品名称Anti-KAT7 / Hbo1 / MYST2抗体
    参阅全部 KAT7 / Hbo1 / MYST2 一抗
  • 描述
    兔多克隆抗体to KAT7 / Hbo1 / MYST2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 2-51 (PRRKRNAGSS SDGTEDSDFS TDLEHTDSSE SDGTSRRSAR VTRSSARLSQ) of Human KAT7/ Hbo1/ MYST2 (NP_008998).

  • 阳性对照
    • OVCAR-3 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab87100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 71 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
  • 组织特异性Ubiquitously expressed, with highest levels in testis.
  • 序列相似性Belongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
  • 结构域The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
    The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus > nucleoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Hbo 1 antibody
    • HBO1 antibody
    • HBOa antibody
    • Histone acetyltransferase binding to hORC1 antibody
    • Histone acetyltransferase binding to ORC1 antibody
    • Histone acetyltransferase KAT7 antibody
    • Histone acetyltransferase MYST2 antibody
    • K(lysine) acetyltransferase 7 antibody
    • KAT 7 antibody
    • KAT7 antibody
    • Lysine acetyltransferase 7 antibody
    • MOZ antibody
    • MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody
    • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody
    • MYST 2 antibody
    • MYST histone acetyltransferase 2 antibody
    • MYST protein 2 antibody
    • MYST-2 antibody
    • MYST2 antibody
    • MYST2_HUMAN antibody
    • SAS 2 antibody
    • SAS2 and TIP60 protein 2 antibody
    • TIP60 protein 2 antibody
    • YBF2/SAS3 antibody
    • ZC2HC7 antibody
    see all

Anti-KAT7 / Hbo1 / MYST2 antibody 图像

  • Anti-KAT7 / Hbo1 / MYST2 antibody (ab87100) at 1 µg/ml (in 5% skim milk / PBS buffer) + 10 µg OVCAR-3 cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG diluted 1/50,000.

    Predicted band size : 71 kDa
    Observed band size : 65 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 40 kDa,50 kDa. We are unsure as to the identity of these extra bands.

Anti-KAT7 / Hbo1 / MYST2 antibody (ab87100)参考文献

ab87100 has not yet been referenced specifically in any publications.

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