Anti-KAT7 / Hbo1 / MYST2抗体(ab37289)

概述

  • 产品名称Anti-KAT7 / Hbo1 / MYST2抗体
    参阅全部 KAT7 / Hbo1 / MYST2 一抗
  • 描述
    兔多克隆抗体to KAT7 / Hbo1 / MYST2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide mapping to the N terminus of Hbo1/ MYST2 (Human).

性能

应用

Our Abpromise guarantee covers the use of ab37289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).
IHC-P Use at an assay dependent concentration. PubMed: 21149574

靶标

  • 功能Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
  • 组织特异性Ubiquitously expressed, with highest levels in testis.
  • 序列相似性Belongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
  • 结构域The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
    The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus > nucleoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Hbo 1 antibody
    • HBO1 antibody
    • HBOa antibody
    • Histone acetyltransferase binding to hORC1 antibody
    • Histone acetyltransferase binding to ORC1 antibody
    • Histone acetyltransferase KAT7 antibody
    • Histone acetyltransferase MYST2 antibody
    • K(lysine) acetyltransferase 7 antibody
    • KAT 7 antibody
    • KAT7 antibody
    • Lysine acetyltransferase 7 antibody
    • MOZ antibody
    • MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody
    • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody
    • MYST 2 antibody
    • MYST histone acetyltransferase 2 antibody
    • MYST protein 2 antibody
    • MYST-2 antibody
    • MYST2 antibody
    • MYST2_HUMAN antibody
    • SAS 2 antibody
    • SAS2 and TIP60 protein 2 antibody
    • TIP60 protein 2 antibody
    • YBF2/SAS3 antibody
    • ZC2HC7 antibody
    see all

Anti-KAT7 / Hbo1 / MYST2 antibody (ab37289)参考文献

This product has been referenced in:
  • Schrötter A  et al. FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease. J Cell Sci 126:2480-92 (2013). Read more (PubMed: 23572515) »
  • Kueh AJ  et al. HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development. Mol Cell Biol 31:845-860 (2011). IHC-P ; Mouse . Read more (PubMed: 21149574) »

See all 2 Publications for this product

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The overall homology between Human and Xenopus is 93%. Thus, in general there is good chance for an antibody raised against human to work in Xenopus.
For ab31506 the homology of the immunogen with Xenopus is 100...

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