概述

  • 产品名称Anti-KAT6B / MORF抗体
    参阅全部 KAT6B / MORF 一抗
  • 描述
    兔多克隆抗体to KAT6B / MORF
  • 特异性This antibody reacts with MORF and MORF alpha.
  • 经测试应用适用于: WB, IHC-P, IPmore details
  • 种属反应性
    与反应: Cow, Human
  • 免疫原

    Synthetic peptide corresponding to Cow KAT6B/ MORF (N terminal) conjugated to keyhole limpet haemocyanin.
    Database link: A7E390

性能

应用

Our Abpromise guarantee covers the use of ab58823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/7500. Detects a band of approximately 230 kDa (predicted molecular weight: 231 kDa).
IHC-P 1/1000.
IP Use at an assay dependent concentration.

靶标

  • 功能Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
  • 组织特异性Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.
  • 疾病相关Note=A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.
  • 序列相似性Belongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
    Contains 1 H15 (linker histone H1/H5 globular) domain.
    Contains 2 PHD-type zinc fingers.
  • 结构域The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
  • 翻译后修饰Autoacetylated.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp313G1618 antibody
    • FLJ90335 antibody
    • Histone acetyltransferase MORF antibody
    • Histone acetyltransferase MOZ2 antibody
    • Histone acetyltransferase MYST4 antibody
    • KAT 6B antibody
    • KIAA0383 antibody
    • Monocytic leukemia zinc finger protein related factor antibody
    • Monocytic leukemia zinc finger protein-related factor antibody
    • MOZ 2 antibody
    • MOZ antibody
    • MOZ related factor antibody
    • MOZ YBF2/SAS3 SAS2 and TIP60 protein 4 antibody
    • MOZ2 antibody
    • MYST 4 antibody
    • MYST histone acetyltransferase (monocytic leukemia) 4 antibody
    • MYST protein 4 antibody
    • MYST-4 antibody
    • MYST4 antibody
    • MYST4_HUMAN antibody
    • OTTHUMP00000019866 antibody
    • OTTHUMP00000019867 antibody
    • OTTHUMP00000019869 antibody
    • OTTHUMP00000019870 antibody
    • QKF antibody
    • Querkopf antibody
    • SAS2 and TIP60 protein 4 antibody
    • YBF2/SAS3 antibody
    see all

Anti-KAT6B / MORF antibody (ab58823)参考文献

This product has been referenced in:
  • Simpson MA  et al. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Am J Hum Genet 90:290-4 (2012). WB . Read more (PubMed: 22265017) »
  • Kraft M  et al. Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. J Clin Invest 121:3479-91 (2011). WB ; Human . Read more (PubMed: 21804188) »

See all 2 Publications for this product

Product Wall

The peptide used to produce this antibody is 90% conserved in a mouse, therefore the antibody is likely to react with mouse.

Thank you for your interest in these products. The secondary antibody used in the study was not from abcam but we do have several similar products in stock. ab6721 is a goat polyclonal to rabbit IgG and has been used extensively in Western blotting whi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"