Anti-KAT5 / Tip60抗体(ab75617)

概述

  • 产品名称Anti-KAT5 / Tip60抗体
    参阅全部 KAT5 / Tip60 一抗
  • 描述
    兔多克隆抗体to KAT5 / Tip60
  • 经测试应用适用于: IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the N terminal region of human KAT5/ Tip60.

  • 阳性对照
    • Human hepatocarcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab75617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/10 - 1/50.
ELISA 1/1000.

靶标

  • 功能Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
  • 序列相似性Belongs to the MYST (SAS/MOZ) family.
    Contains 1 C2HC-type zinc finger.
  • 翻译后修饰Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
    Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. Phosphorylated form has a higher activity.
    Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
  • 细胞定位Nucleus > nucleolus. Cytoplasm > perinuclear region. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 60 kDa Tat interactive protein antibody
    • 60 kDa Tat-interactive protein antibody
    • cPLA(2) interacting protein antibody
    • cPLA(2)-interacting protein antibody
    • cPLA2 antibody
    • cPLA2 interacting protein antibody
    • ESA1 antibody
    • Histone acetyltransferase HTATIP antibody
    • Histone acetyltransferase KAT5 antibody
    • HIV 1 Tat interactive protein antibody
    • HIV 1 Tat interactive protein, 60kDa antibody
    • HIV-1 Tat interactive protein antibody
    • HTATIP antibody
    • HTATIP1 antibody
    • K(lysine) acetyltransferase 5 antibody
    • K-acetyltransferase 5 antibody
    • KAT5 antibody
    • KAT5_HUMAN antibody
    • Lysine acetyltransferase 5 antibody
    • PLIP antibody
    • Tat interacting protein, 60kDa antibody
    • TIP antibody
    • Tip60 antibody
    see all

Anti-KAT5 / Tip60 antibody 图像

  • ab75617, at a 1/10 dilution, staining KAT5 / Tip60 in formalin fixed, paraffin embedded human hepatocarcinoma tissue by Immunohistochemistry. ab75617 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-KAT5 / Tip60 antibody (ab75617)参考文献

ab75617 has not yet been referenced specifically in any publications.

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