Anti-KAT3A / CBP抗体, prediluted (ab53901)

概述

  • 产品名称Anti-KAT3A / CBP抗体, prediluted
    参阅全部 KAT3A / CBP 一抗
  • 描述
    兔多克隆抗体to KAT3A / CBP, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    AGGMAGHGQFQQPQGPGGYP

    , corresponding to amino acids 2422-2441 of Human CBP

  • 阳性对照
    • Hela cells and tonsil tissue

应用

Our Abpromise guarantee covers the use of ab53901 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready-to-use, treat for 30 min at RT.
    Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
    • 疾病相关Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
      Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
    • 序列相似性Contains 1 bromo domain.
      Contains 1 KIX domain.
      Contains 2 TAZ-type zinc fingers.
      Contains 1 ZZ-type zinc finger.
    • 结构域The KIX domain mediates binding to HIV-1 Tat.
    • 翻译后修饰Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
      Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.
    • 细胞定位Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CBP antibody
      • CBP_HUMAN antibody
      • CREB binding protein antibody
      • CREB-binding protein antibody
      • Crebbp antibody
      • Cyclic AMP responsive enhancer binding protein antibody
      • KAT3A antibody
      • RSTS antibody
      • RTS antibody
      • Rubinstein Taybi syndrome antibody
      see all

    Anti-KAT3A / CBP antibody, prediluted 图像

    • Human tonsil tissue stained with neat ab53901

    Anti-KAT3A / CBP antibody, prediluted (ab53901)参考文献

    ab53901 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"