Anti-KAT3A / CBP抗体(ab83857)

概述

  • 产品名称Anti-KAT3A / CBP抗体
    参阅全部 KAT3A / CBP 一抗
  • 描述
    兔多克隆抗体to KAT3A / CBP
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 144 - 193 (TPAASQALNP QAQKQVGLAT SSPATSQTGP GICMNANFNQ THPGLLNSNS) of Human KAT3A/ CBP (NP_001073315)

  • 阳性对照
    • Jurkat cell lysate.

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应用

Our Abpromise guarantee covers the use of ab83857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 265 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
  • 疾病相关Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
    Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
  • 序列相似性Contains 1 bromo domain.
    Contains 1 KIX domain.
    Contains 2 TAZ-type zinc fingers.
    Contains 1 ZZ-type zinc finger.
  • 结构域The KIX domain mediates binding to HIV-1 Tat.
  • 翻译后修饰Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.
  • 细胞定位Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CBP antibody
    • CBP_HUMAN antibody
    • CREB binding protein antibody
    • CREB-binding protein antibody
    • Crebbp antibody
    • Cyclic AMP responsive enhancer binding protein antibody
    • KAT3A antibody
    • RSTS antibody
    • RTS antibody
    • Rubinstein Taybi syndrome antibody
    see all

Anti-KAT3A / CBP antibody 图像

  • Anti-KAT3A / CBP antibody (ab83857) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 265 kDa
  • ab83857 at 5 µg/ml staining KAT3A / CBP in Human breast tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
  • ab83857 at 5 µg/ml staining KAT3A / CBP in Human colon tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-KAT3A / CBP antibody (ab83857)参考文献

ab83857 has not yet been referenced specifically in any publications.

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