概述

  • 产品名称
    Anti-KAT2B / PCAF抗体
    参阅全部 KAT2B / PCAF 一抗
  • 描述
    兔多克隆抗体to KAT2B / PCAF
  • 经测试应用
    适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide, corresponding to a region within the C terminal amino acids 767-832 of Human KAT2B/ PCAF.

  • 阳性对照
    • 293T, A431, H1299, HeLa S3, HepG2, MOLT4, Raji cells, HeLa cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab96510 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 93 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能
    Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
  • 组织特异性
    Ubiquitously expressed but most abundant in heart and skeletal muscle.
  • 序列相似性
    Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • 结构域
    The bromodomain mediates binding to HIV-1 Tat.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAF antibody
    • CREBBP associated factor antibody
    • GCN5 antibody
    • GCN5L antibody
    • GCN5L1 antibody
    • Histone acetylase PCAF antibody
    • Histone acetyltransferase KAT2B antibody
    • Histone acetyltransferase PCAF antibody
    • K(lysine) acetyltransferase 2B antibody
    • KAT2B antibody
    • KAT2B_HUMAN antibody
    • Lysine acetyltransferase 2B antibody
    • P antibody
    • P/CAF antibody
    • p300/CBP associated factor antibody
    • P300/CBP-associated factor antibody
    • Pcaf antibody
    see all

图片

  • Anti-KAT2B / PCAF antibody (ab96510) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 93 kDa
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab96510 at 1:200 dilution. Image 2: Merged with DNA probe.

文献

This product has been referenced in:
  • Shirakawa K  et al. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife 5:N/A (2016). WB . Read more (PubMed: 27244239) »

See 1 Publication for this product

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