Anti-KAT2B / PCAF抗体(ab110421)

概述

  • 产品名称Anti-KAT2B / PCAF抗体
    参阅全部 KAT2B / PCAF 一抗
  • 描述
    兔多克隆抗体to KAT2B / PCAF
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rabbit, Horse, Chicken, Cow, Dog, Chimpanzee, Macaque Monkey, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human KAT2B/ PCAF.

  • 阳性对照
    • This antibody gave a positive signal in both Human and Mouse Skeletal Muscle tissue lysates.

性能

应用

Our Abpromise guarantee covers the use of ab110421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 93 kDa (predicted molecular weight: 93 kDa).

靶标

  • 功能Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
  • 组织特异性Ubiquitously expressed but most abundant in heart and skeletal muscle.
  • 序列相似性Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • 结构域The bromodomain mediates binding to HIV-1 Tat.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAF antibody
    • CREBBP associated factor antibody
    • GCN5 antibody
    • GCN5L antibody
    • GCN5L1 antibody
    • Histone acetylase PCAF antibody
    • Histone acetyltransferase KAT2B antibody
    • Histone acetyltransferase PCAF antibody
    • K(lysine) acetyltransferase 2B antibody
    • KAT2B antibody
    • KAT2B_HUMAN antibody
    • Lysine acetyltransferase 2B antibody
    • P antibody
    • P/CAF antibody
    • p300/CBP associated factor antibody
    • P300/CBP-associated factor antibody
    • Pcaf antibody
    see all

Anti-KAT2B / PCAF antibody 图像

  • All lanes : Anti-KAT2B / PCAF antibody (ab110421) at 1 µg/ml (Milk blocking - 3%)

    Lane 1 : Human skeletal muscle tissue lysate - total protein (ab29330)
    Lane 2 : Skeletal Muscle (Mouse) Tissue Lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 93 kDa
    Observed band size : 93 kDa
    Additional bands at : 46 kDa,55 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 3 minutes

Anti-KAT2B / PCAF antibody (ab110421)参考文献

ab110421 has not yet been referenced specifically in any publications.

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