概述

性能

应用

Our Abpromise guarantee covers the use of ab18381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/500. Predicted molecular weight: 94 kDa.

靶标

  • 功能Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • 组织特异性Expressed in all tissues tested, with most abundant expression in ovary.
  • 序列相似性Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110051E14Rik antibody
    • AW212720 antibody
    • EC 2.3.1.48 antibody
    • GCN 5 antibody
    • GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2 antibody
    • Gcn5 antibody
    • GCN5 general control of amino-acid synthesis 5-like 2 (yeast) antibody
    • GCN5L2 antibody
    • general control of amino acid synthesis 5-like 2 antibody
    • General control of amino acid synthesis protein 5-like 2 antibody
    • General control of amino acid synthesis, yeast, homolog-like 2 antibody
    • HGCN5 antibody
    • Histone acetyltransferase GCN5 antibody
    • Histone acetyltransferase KAT2A antibody
    • hsGCN5 antibody
    • K(lysine) acetyltransferase 2A antibody
    • KAT2 A antibody
    • KAT2A antibody
    • KAT2A_HUMAN antibody
    • Lysine acetyltransferase 2A antibody
    • MGC102791 antibody
    • PCAF-b antibody
    • STAF97 antibody
    see all

Anti-KAT2A / GCN5 antibody 图像

  • ab18381 at 2ug/ml staining human spleen tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). The tissue was fixed and blocked and incubated with the antibody for 30 minutes. An HRP conjugated goat antibody was used as the secondary.

    See Abreview

Anti-KAT2A / GCN5 antibody (ab18381)参考文献

This product has been referenced in:
  • Liu Y  et al. Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18. FEBS Lett 587:847-53 (2013). Read more (PubMed: 23434580) »
  • Pearen MA  et al. Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance. Mol Endocrinol 27:1897-917 (2013). Mouse . Read more (PubMed: 24065705) »

See all 6 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (spleen)
Specification spleen
Antigen retrieval step Heat mediated
Blocking step Dako CSA II blocker as blocking agent for 5 minute(s) · Concentration: 100
Username

Abcam user community

Verified customer

提交于 Jan 12 2007

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - whole cell (primary muscle cells)
Specification primary muscle cells
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 4%
Username

Abcam user community

Verified customer

提交于 Aug 16 2005

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"