Anti-KAT13D / CLOCK抗体(ab93804)


  • 产品名称
    Anti-KAT13D / CLOCK抗体
    参阅全部 KAT13D / CLOCK 一抗
  • 描述
    兔多克隆抗体to KAT13D / CLOCK
  • 宿主
  • 经测试应用
    适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Guinea pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 796-846 of Human KAT13D/ CLOCK (NP_004889.1)

  • 阳性对照
    • HeLa and 293T whole cell lysate


Our Abpromise guarantee covers the use of ab93804 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明
    IP: Use at a concentration of 2-5 µg/ml.
    WB: 1/2000 - 1/10000. Predicted molecular weight: 95 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL.
    • 组织特异性
      Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).
    • 序列相似性
      Contains 1 basic helix-loop-helix (bHLH) domain.
      Contains 1 PAC (PAS-associated C-terminal) domain.
      Contains 2 PAS (PER-ARNT-SIM) domains.
    • 翻译后修饰
      Phosphorylation is dependent on CLOCK-ARNTL heterodimer formation.
    • 细胞定位
      Cytoplasm. Nucleus. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • bHLHe8 antibody
      • Circadian locomoter output cycles kaput protein antibody
      • Circadian locomoter output cycles protein kaput antibody
      • Circadian Locomotor Output Cycles Kaput antibody
      • Circadium Locomotor Output Cycles Kaput antibody
      • Class E basic helix-loop-helix protein 8 antibody
      • CLOCK antibody
      • Clock circadian regulator antibody
      • Clock homolog antibody
      • Clock protein antibody
      • CLOCK_HUMAN antibody
      • hCLOCK antibody
      • KIAA0334 antibody
      see all


    • All lanes : Anti-KAT13D / CLOCK antibody (ab93804) at 0.1 µg/ml

      Lane 1 : HeLa at 50 µg
      Lane 2 : HeLa at 15 µg
      Lane 3 : HeLa at 5 µg
      Lane 4 : 293T at 50 µg

      Developed using the ECL technique.

      Predicted band size: 95 kDa

      Exposure time: 3 minutes
    • ab93804 at 1 µg/ml detecting KAT13D/CLOCK in HeLa whole cell lysate by WB following IP.
      Lane 1: IP with an antibody which recognizes an upstream epitope of KAT13D/CLOCK
      Lane 2: ab93804 at 3µg/mg of lysate
      Lane 3: control IgG.
      In each case, 1 mg of lysate was used for IP and 20% of the IP was loaded.
      Detection: Chemiluminescence with an exposure time of 30 seconds

      All lanes : Anti-KAT13D / CLOCK antibody (ab93804)

      Lane 1 : IP ab93804
      Lane 2 : IP KAT13D / CLOCK antibody
      Lane 3 : control IgG

      Lysates/proteins at 3 µg/ml per lane.


    ab93804 has not yet been referenced specifically in any publications.


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