Anti-KAT13C / NCOA2抗体(ab94502)

概述

• 产品名称
  Anti-KAT13C / NCOA2抗体
  参阅全部 KAT13C / NCOA2 一抗
• 描述
  兔多克隆抗体to KAT13C / NCOA2
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
• 免疫原

  Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (

  SGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAE

  ) of Human KAT13C/ NCOA2 (NP_006531)

  Run BLAST with Run BLAST with
• 阳性对照
  • Human fetal thymus lysate

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Mediator Complex

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Obesity

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.
• 疾病相关
  Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
• 序列相似性
  Belongs to the SRC/p160 nuclear receptor coactivator family.
  Contains 1 bHLH (basic helix-loop-helix) domain.
  Contains 1 PAS (PER-ARNT-SIM) domain.
• 结构域
  Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
  The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
  Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
• 翻译后修饰
  Phosphorylated upon DNA damage, probably by ATM or ATR.
• 细胞定位
  Nucleus.

• Target information above from: UniProt accession Q15596 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 10499 Human
  • Entrez Gene: 17978 Mouse
  • Entrez Gene: 83724 Rat
  • Omim: 601993 Human
  • SwissProt: Q15596 Human
  • SwissProt: Q61026 Mouse
  • SwissProt: Q9WUI9 Rat
  • Unigene: 446678 Human

  • Unigene: 2537 Mouse
  • Unigene: 49136 Rat

  see all
• 别名
  • bHLHe75 antibody
  • Class E basic helix-loop-helix protein 75 antibody
  • glucocorticoid receptor interacting protein 1 antibody

  • GRIP 1 antibody
  • GRIP1 antibody
  • hTIF2 antibody
  • MED1 antibody
  • MGC138808 antibody
  • NCoA 2 antibody
  • NCoA-2 antibody
  • Ncoa2 antibody
  • NCOA2_HUMAN antibody
  • Nuclear receptor coactivator 2 antibody
  • Oncogene FGR antibody
  • p160 antibody
  • SRC 2 antibody
  • src2 antibody
  • Steroid receptor coactivator 2 antibody
  • TIF 2 antibody
  • TIF2 antibody
  • Transcriptional intermediary factor 2 antibody

  see all

实验方案

• Western blot protocols