Anti-KAT13C / NCOA2抗体(ab84140)


  • 产品名称Anti-KAT13C / NCOA2抗体
    参阅全部 KAT13C / NCOA2 一抗
  • 描述
    兔多克隆抗体to KAT13C / NCOA2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region within residues 1400 and the C terminus (1464) of human KAT13C/ NCOA2 (NP_006531.1).

  • 阳性对照
    • Human breast adenocarcinoma; human prostate adenocarcinoma.



Our Abpromise guarantee covers the use of ab84140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.
    • 疾病相关Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
    • 序列相似性Belongs to the SRC/p160 nuclear receptor coactivator family.
      Contains 1 bHLH (basic helix-loop-helix) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
    • 结构域Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
      The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
      Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • bHLHe75 antibody
      • Class E basic helix-loop-helix protein 75 antibody
      • glucocorticoid receptor interacting protein 1 antibody
      • GRIP 1 antibody
      • GRIP1 antibody
      • hTIF2 antibody
      • MED1 antibody
      • MGC138808 antibody
      • NCoA 2 antibody
      • NCoA-2 antibody
      • Ncoa2 antibody
      • NCOA2_HUMAN antibody
      • Nuclear receptor coactivator 2 antibody
      • Oncogene FGR antibody
      • p160 antibody
      • SRC 2 antibody
      • src2 antibody
      • Steroid receptor coactivator 2 antibody
      • TIF 2 antibody
      • TIF2 antibody
      • Transcriptional intermediary factor 2 antibody
      see all

    Anti-KAT13C / NCOA2 antibody 图像

    • ab84140, at a 1/250 dilution, staining KAT13C / NCOA2 in formalin fixed, paraffin embedded human breast adenocarcinoma tissue by Immunohistochemistry.
      Detection: DAB
    • ab84140, at a 1/100 dilution, staining KAT13C / NCOA2 in formalin fixed, paraffin embedded human prostate adenocarcinoma by Immunohistochemistry.
      Detection: DAB

    Anti-KAT13C / NCOA2 antibody (ab84140)参考文献

    ab84140 has not yet been referenced specifically in any publications.

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