Anti-KAT13A / SRC1抗体[3532C6a] (ab67101)


  • 产品名称Anti-KAT13A / SRC1抗体[3532C6a]
    参阅全部 KAT13A / SRC1 一抗
  • 描述
    小鼠单克隆抗体[3532C6a] to KAT13A / SRC1
  • 经测试应用适用于: WB, Dot Blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment corresponding to Human KAT13A/ SRC1 (internal sequence).
    Database link: Q15788



Our Abpromise guarantee covers the use of ab67101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot Blot
  • 应用说明Dot: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Detects a band of approximately 37 kDa (predicted molecular weight of full length protein: 160 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
    • 组织特异性Widely expressed.
    • 疾病相关Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
    • 序列相似性Belongs to the SRC/p160 nuclear receptor coactivator family.
      Contains 1 basic helix-loop-helix (bHLH) domain.
      Contains 1 PAS (PER-ARNT-SIM) domain.
    • 结构域The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
      Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.
    • 翻译后修饰Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
      Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • bHLHe74 antibody
      • Class E basic helix-loop-helix protein 74 antibody
      • F SRC 1 antibody
      • Hin 2 protein antibody
      • Hin2 protein antibody
      • MGC129719 antibody
      • MGC129720 antibody
      • mNRC 1 antibody
      • NCoA 1 antibody
      • NCoA-1 antibody
      • Ncoa1 antibody
      • NCOA1_HUMAN antibody
      • Nuclear receptor coactivator 1 antibody
      • Nuclear receptor coactivator protein 1 antibody
      • NY REN 52 antigen antibody
      • Protein Hin 2 antibody
      • Protein Hin-2 antibody
      • Protein Hin2 antibody
      • Renal carcinoma antigen NY REN 52 antibody
      • Renal carcinoma antigen NY-REN-52 antibody
      • RIP 160 antibody
      • RIP160 antibody
      • SRC 1 antibody
      • SRC-1 antibody
      • Steroid receptor coactivator 1 antibody
      see all

    Anti-KAT13A / SRC1 antibody [3532C6a] 图像

    • Anti-KAT13A / SRC1 antibody [3532C6a] (ab67101) + immunising recombinant fragment

      Predicted band size : 160 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

      Western blot analysis of immunized recombinant protein using anti-NCOA1 monoclonal antibody

    Anti-KAT13A / SRC1 antibody [3532C6a] (ab67101)参考文献

    ab67101 has not yet been referenced specifically in any publications.

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