概述

  • 产品名称Anti-KAT1 / HAT1抗体
    参阅全部 KAT1 / HAT1 一抗
  • 描述
    兔多克隆抗体to KAT1 / HAT1
  • 特异性ab61225 detects endogenous levels of total HAT protein
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide derived from an internal region of human HAT1.

  • 阳性对照
    • Extracts from LOVO cells

性能

应用

Our Abpromise guarantee covers the use of ab61225 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
WB 1/500 - 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

靶标

  • 功能Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
  • 序列相似性Belongs to the HAT1 family.
  • 发展阶段Highly expressed in mitotic cells (at protein level).
  • 细胞定位Nucleus matrix and Cytoplasm. Nucleus. Nucleus matrix. Nucleus > nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HAT 1 antibody
    • hat1 antibody
    • HAT1_HUMAN antibody
    • Histidine aminotransferase 1 antibody
    • Histone acetyltransferase 1 antibody
    • Histone acetyltransferase 1 antibody
    • Histone acetyltransferase type B catalytic subunit antibody
    • KAT1 antibody
    see all

Anti-KAT1 / HAT1 antibody 图像

  • All lanes : Anti-KAT1 / HAT1 antibody (ab61225) at 1/500 dilution

    Lane 1 : extracts from LOVO cells
    Lane 2 : extracts from LOVO cells with immunizing peptide


    Predicted band size : 49 kDa
    Observed band size : 49 kDa

Anti-KAT1 / HAT1 antibody (ab61225)参考文献

This product has been referenced in:
  • Zhou X  et al. Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2. PLoS One 9:e107231 (2014). WB ; Mouse . Read more (PubMed: 25222566) »
  • Ejlassi-Lassallette A  et al. H4 replication-dependent diacetylation and Hat1 promote S-phase chromatin assembly in vivo. Mol Biol Cell 22:245-55 (2011). WB ; Other . Read more (PubMed: 21118997) »

See all 2 Publications for this product

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