概述

  • 产品名称
    Anti-KAT1 / HAT1抗体
    参阅全部 KAT1 / HAT1 一抗
  • 描述
    兔多克隆抗体to KAT1 / HAT1
  • 特异性
    ab12163 specifically recognizes human HAT1.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Chicken, Human
  • 免疫原

    Synthetic peptide:

    EESFQELVEDYRRVIERLAQE

    with N-terminal added lysine conjugated to KLH, corresponding to amino acids 399-419 of Human HAT1. The corresponding sequence differs by three amino acids in chicken and by one amino acid in mouse (putative sequence).

  • 阳性对照
    • Whole extracts of human 293 cells, mouse NIH-3T3 cells, or chicken fibroblasts.
  • 常规说明
    Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

性能

应用

Our Abpromise guarantee covers the use of ab12163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2500. Detects a band of approximately 46 kDa.

靶标

  • 功能
    Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
  • 序列相似性
    Belongs to the HAT1 family.
  • 发展阶段
    Highly expressed in mitotic cells (at protein level).
  • 细胞定位
    Nucleus matrix and Cytoplasm. Nucleus. Nucleus matrix. Nucleus > nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HAT 1 antibody
    • hat1 antibody
    • HAT1_HUMAN antibody
    • Histidine aminotransferase 1 antibody
    • Histone acetyltransferase 1 antibody
    • Histone acetyltransferase 1 antibody
    • Histone acetyltransferase type B catalytic subunit antibody
    • KAT1 antibody
    see all

实验方案

文献

ab12163 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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