概述
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产品名称Anti-KAT1 / HAT1抗体
参阅全部 KAT1 / HAT1 一抗 -
描述兔多克隆抗体to KAT1 / HAT1
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宿主Rabbit
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经测试应用适用于: WBmore details
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种属反应性与反应: Mouse, Chicken, Human
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免疫原
Synthetic peptide:
EESFQELVEDYRRVIERLAQE
with N-terminal added lysine conjugated to KLH, corresponding to amino acids 399-419 of Human HAT1. The corresponding sequence differs by three amino acids in chicken and by one amino acid in mouse (putative sequence). -
阳性对照
- Whole extracts of human 293 cells, mouse NIH-3T3 cells, or chicken fibroblasts.
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常规说明Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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存储溶液Preservative: 15mM Sodium Azide
Constituents: 1% BSA, 0.01M PBS, pH 7.4 -
Concentration information loading... -
纯度Immunogen affinity purified
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纯化说明The antibody is affinity-purified using the immunizing peptide immobilized on agarose.
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab12163 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/2500. Detects a band of approximately 46 kDa. |
靶标
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功能Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
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序列相似性Belongs to the HAT1 family.
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发展阶段Highly expressed in mitotic cells (at protein level).
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细胞定位Nucleus matrix and Cytoplasm. Nucleus. Nucleus matrix. Nucleus > nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
- Information by UniProt
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数据库链接
- Entrez Gene: 374037 Chicken
- Entrez Gene: 8520 Human
- Entrez Gene: 107435 Mouse
- Omim: 603053 Human
- SwissProt: O14929 Human
- SwissProt: Q8BY71 Mouse
- Unigene: 632532 Human
- Unigene: 272472 Mouse
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别名
- HAT 1 antibody
- hat1 antibody
- HAT1_HUMAN antibody
see all
文献
ab12163 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"