Anti-Karyopherin beta 3抗体(ab55390)

概述

  • 产品名称Anti-Karyopherin beta 3抗体
    参阅全部 Karyopherin beta 3 一抗
  • 描述
    小鼠单克隆抗体to Karyopherin beta 3
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR NTTAAEEARQ MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME , corresponding to amino acids 1-101 of Human Karyopherin (importin) beta 3

性能

应用

Our Abpromise guarantee covers the use of ab55390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
    • 序列相似性Belongs to the importin beta family.
      Contains 6 HEAT repeats.
      Contains 1 importin N-terminal domain.
    • 细胞定位Cytoplasm. Nucleus. Nucleus > nucleolus. Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp686O1576 antibody
      • FLJ43041 antibody
      • IMB3 antibody
      • Imp5 antibody
      • Importin 5 antibody
      • Importin beta 3 subunit antibody
      • Importin subunit beta 3 antibody
      • Importin subunit beta-3 antibody
      • Importin-5 antibody
      • IPO 5 antibody
      • IPO5 antibody
      • IPO5_HUMAN antibody
      • Karyopherin beta 3 antibody
      • Karyopherin beta-3 antibody
      • KPNB3 antibody
      • MGC2068 antibody
      • Pse1 antibody
      • Ran binding protein 5 antibody
      • Ran GTP binding protein 5 antibody
      • Ran-binding protein 5 antibody
      • RanBP 5 antibody
      • RanBP5 antibody
      see all

    Anti-Karyopherin beta 3 antibody 图像

    • Karyopherin (importin) beta 3 antibody (ab55390) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human pancreas.


    • Predicted band size : 124 kDa
      Karyopherin (importin) beta 3 antibody (ab55390) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-Karyopherin beta 3 antibody (ab55390)参考文献

    ab55390 has not yet been referenced specifically in any publications.

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